What is the best way to facilitate payouts to users bank accounts?

What is the best way to facilitate payouts to user bank accounts?

After checking with my local bank wire-transfers are $25 each and can't be triggered programmatically. Where else should I explore for the ability to do this?

You should look at ACH or EFT transfers. Someone like paymentsgateway.net has a programmatic interface for transferring funds from your bank account to the users bank account. There are many interfaces to ACH it just takes some looking.

Edit: Wire transfers are typically for larger amounts of money.

Seriously?

After checking with my local bank wire-transfers are $25 each and can't be triggered
programmatically.

Get a bank that can deal with that for a decent price. That simple.